Ryan Watson, Luke Durham, Wayne Brooke, Gary Collier and William Ramsden got their goals, countering home strikes from Scott Sullivan, Simon Castle, Brad Swainstone and Rob Hart.
Second division Derwent United shocked first division high-fliers Acomb Celtic 6-4 with goals from Dave Bradshaw (2), Marcus Godsell (2), Dan Fog and Kingsley Daffern.
Celtic replied through Lee Powell (2), Stuart Nichol and Cameron Sanderson.
Hemingbrough United reached the last eight by brushing aside Skelton 5-0. Hemingbrough, 1-0 up at the break through Tom Collins, never looked in danger of losing the tie when an own goal doubled their lead just after the restart. Collins then completed a hat-trick with goals either side of a Luke Zacharenko strike.
York Nomads, with braces from Nick Lawrie, Liam Wingfield and John Cavanagh, plus a Chris Bilton strike, saw off Marcia Grey 7-0.
Wiggington Grasshoppers came from a goal down at half-time to beat Hounds 4-1.
The first half had seen chances at both ends, the goal coming when Ben Ollson pounced on a back pass that left the Hoppers goalkeeper in no man’s land. The home side hit back after the break as Lee McQuade scored with a diving header before Lee Stewart bagged a brace.
Enterprise beat Leeman United 5-2. Enterprise went two up through an own goal and a Scott Nicholas strike but United levelled through Craig Fletcher and Neil Hartley. Charles Hartley hit Enterprise’s third just before the break, before, in the turning point of the game, substitute Paul Bentley came off the bench to grab two goals to seal the result.
A new name will be on the Ian’s Cars of Barlby Junior Trophy after holders York Five Lions were beaten 6-2 at NUR.
Danny Cotton (2) and Peter Knight put NUR 3-0 up before Lions hit back through Daniel Wood and Sean Stockdale.
Cotton hit his third before half-time lead and, in the second period, Matty Rockett made it 5-2 before Cotton took his tally to four.
On target for Magnets were Ben Wilson (2), Philip Biscombe, Kingsley Wetherald and Tom Deighton, Rovers’ lone reply coming from Chris Johnson.
Dark horses Albion Vaults reached the quarter-finals by seeing off LNER Builders 7-0 with goals from Steve Rowbottom (2), Dave Hulla (2), Paul Tanton, Max Chambers and Chris Coxon.
Stuart Dickinson netted eight times in Marcia Bishopthorpe’s 13-0 hammering of York Phoenix.
Also finding the net were Dallan Tooley (2), Martin Charlton (2) and Bill Hetherington.
Rob Guest’s hat-trick gave Brayton a 3-1 win over Eggborough Rangers, who replied through James Newnham.
In the only tie to be decided after extra time, New Earswick beat Britannia Tadcaster 5-3. On target for the villagers were Kevin Martin (2), Greg Lowther (2) and Jon Thompson.